Bayer Leverkusen headed into the winter break in a strong fourth spot after finally finding more stability this season. They are unbeaten in 12 Bundesliga matches and have not lost at home this season, while boasting the league's third-best attack overall.
Bayern found stability after former manger Jupp Heynckes returned to the club and replacement Carlo Ancelotti in October. They have won four straight Bundesliga matches and sit a comfortable 11 points ahead of second-placed Schalke.
Expect this to be an intense game between two of the Bundesliga's best sides so far, with Bayern being slight favourites to edge it.
The hosts have acted fast in the transfer window, making three signings in the first 10 days of the window. Whether they can provide the inspiration the Blades need to jump back into the play-off places remains to be seen.
New Sheffield Wednesday boss Jos Luhukay has the opportunity to kick his spell with the Owls off in the best possible way with a derby win over Sheffield United here. However, with the Owls in a poor run of form and struggling with injuries, it's not going to be an easy task.
Both sides will be desperate not to lose this Steel City derby, but defeat for the visitors looks probable and will leave Jos Luhukay looking over his shoulder at the start of his tenure in charge.